The scientists studied the electrodes to record neuron activity as new memories were being created. They then used a video game featuring a taxi cab, virtual passengers and a cyber-city, to test if deep-brain stimulation of the entorhinal cortex or the hippocampus altered recall. Patients played the role of cab drivers who picked up passengers and traveled across town to deliver them to one of six requested shops. Fried continued that : When we stimulated the nerve fibers in the patients' entorhinal cortex during learning, they later recognized landmarks and navigated the routes more quickly . They even learned to take shortcuts, reflecting improved spatial memory .
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Critically, it was the stimulation at the gateway into the hippocampus . Stimulation appears to only be necessary during the learning phase. Thus continuous stimulation to boost memory is not necessary, only when someone is trying to learn important information. In theory, this could lead researchers to develop neuro-prosthetic devices that can activate during certain stages of information processing or daily tasks. Six million Americans and 30 million people worldwide are diagnosed with Alzheimer's disease each year. The progressive disorder is the sixth leading cause of death in the United States and the fifth leading cause of death for those aged 65 and older. Losing our ability to remember recent events and form new memories is one of the most dreaded afflictions of the human condition .
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