It is most commonly caused by GERD (gastroesophageal reflux disease, GORD in British English). Sometimes the condition may be caused by more than one factor. Esophagitis may be caused by: GERD - known as reflux esophagitis. There is a valve which stops acids from seeping back up into the esophagus, it is called the esophageal sphincter. If it is faulty - does not flap closed and open properly, stomach contents can reflux; make their way back up into the esophagus, effectively GERD. GERD can irritate the esophagus, leading to esophagitis. Allergies - they can cause eosinophilic esophagitis, triggered by an allergic reaction, usually to one or two foods.
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An eosinophil is a type of white blood cell (leukocyte). When there is an allergic reaction or a parasitic infection, the numbers of eosinophils in the blood usually rise. If eosinophils crowd the esophagus it will become inflamed. Some medications - known as drug-induced esophagitis - if in contact with the esophagus lining for too long, some oral medications can cause inflammation. This can happen if an oral medication is swallowed without washing it down with enough water. Residue from the tablet, pill or capsule may stay in the esophagus. Most commonly, it can occur with some painkillers, antibiotics, drugs to treat potassium deficiency (potassium chloride), and certain drugs for the treatment for osteoporosis, such as Fosamax (alendronate). People who are immunocompromised (have weakened immune systems) are more susceptible. Infectious esophagitis can be caused by candida (esophageal candidiasis), herpes simplex, and cytomegalovirus.
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